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VOLUME 2 - NUMBER 3 - 2025
Blastocyst re-expansion and implantation in FER
- Francesco Capodanno, Sofia Bertolini, Daria Marzanati, Luca Pagliardini, Lucia De Santis, Andrea Gallinelli
- Original Article, 40-45
- Full text PDF
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Purpose: This study aimed to assess the feasibility and value of blastocyst re-expansion timing as a predictor of embryo implantation in Frozen Embryo Replacement (FER). Methods: One hundred and sixty-for patients submitted to 205 single FER were enrolled in the period between September 2021 and April 2023 at the Physiopathology of Reproduction and IVF Unit, Hospital del Delta, AUSL Ferrara, Italy. Blastocysts re-expansion timing has been retrospectively correlated to the implantation.
Results: The results indicated a significantly higher implantation rate for fully re-expanded blastocysts compared to non-re-expanded ones 4 hours post-warming. The exact timing of re-expansion did not demonstrate a significant correlation with implantation potential, whereas the completion of re-expansion within 4 hours post-warming did. The quality of the pre-vitrification Inner Cell Mass (ICM) and Trophectoderm (TE) also significantly influenced implantation potential, reinforcing the importance of these pre-vitrification factors. Conclusions: This study highlights the significance of pre-vitrification ICM and TE quality and the complete re-expansion of blastocysts within 4 hours post-warming as strong predictors of embryo implantation in frozen embryo-transfer cycles. These findings offer valuable insights for clinical practice in optimizing the success of FER. -
KEY WORDS: Blastocyst re-expansion; vitrification; implantation potential; FER.